Peptide-mediated immunoregulation
| Autor: | J. R. Lamb, Charlotte Hetzel, Gerard F. Hoyne |
|---|---|
| Předmět: |
medicine.medical_treatment
T cell Immunology Antigen presentation Biology Immune tolerance Mice Th2 Cells Immune system Hypersensitivity Immune Tolerance medicine Animals Humans Immunology and Allergy Antigen-presenting cell Glycoproteins Antigen Presentation General Medicine Immunotherapy Allergens Th1 Cells Peptide Fragments Cell biology Cytokine medicine.anatomical_structure Desensitization Immunologic Cats Cytokines Cytokine secretion |
| Zdroj: | Scopus-Elsevier |
| Popis: | Quantitative and qualitative characteristics of the signals received by a T cell determine whether receptor ligation results in cell activation, cell death, or the induction of antigen-specific non-responsiveness. Environmental factors such as the nature of costimulation, antigen-presenting cell type, peptide structure and cytokine levels also influence the differentiation of CD4+ helper T cells into functionally distinct subsets, which now appear pivotal in many immune-mediated disorders, including autoimmunity and allergy. Selective manipulation of the immune response, such as the functional inactivation or deviation of the cytokine secretion patterns of specific T cells, may be an effective strategy for immunotherapy. |
| Databáze: | OpenAIRE |
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