Identification of susceptibility variants in ADIPOR1 gene associated with type 2 diabetes, coronary artery disease and the comorbidity of type 2 diabetes and coronary artery disease

Autor: Xiang Li, Xiaohong Shi, Fan Yang, Lianmei Pu, Duo Yang, Liang Sun, Weijun Chen, Fan Zhao, Chen-Guang Zheng, Xiaoquan Zhu, Zhang Yurong, Wang Nana, Huagang Zhu, Ze Yang, Hong Li, Ruofei Jia, Shuai Meng, Zening Jin, Wandong Zhang, Xinmiao Yang, Yi-Ge Yang, Hui Juan, Qin Zhou, Nan Nan
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Oncology
genetic association
Genotyping Techniques
endocrine system diseases
Epidemiology
genotype
Gene Identification and Analysis
lcsh:Medicine
Comorbidity
Coronary Artery Disease
Type 2 diabetes
genetic risk
Vascular Medicine
Coronary artery disease
single nucleotide polymorphism
Ethnicity
Medicine and Health Sciences
lcsh:Science
Genetics
Multidisciplinary
non insulin dependent diabetes mellitus
adult
Han Chinese
Middle Aged
Type 2 Diabetes
Phenotype
Research Design
Genetic Epidemiology
Female
Receptors
Adiponectin
Research Article
medicine.medical_specialty
Clinical Research Design
Single-nucleotide polymorphism
adiponectin receptor 1
Research and Analysis Methods
Polymorphism
Single Nucleotide
Asian People
Internal medicine
Diabetes Mellitus
medicine
Humans
Genetic Predisposition to Disease
cardiovascular diseases
Allele
Genetic Association Studies
AdipoR1 gene
Aged
Evolutionary Biology
Adiponectin
business.industry
lcsh:R
Case-control study
Biology and Life Sciences
nutritional and metabolic diseases
Human Genetics
Odds ratio
case control study
medicine.disease
major clinical study
Diabetes Mellitus
Type 2
Case-Control Studies
Metabolic Disorders
Genetics of Disease
Genetic Polymorphism
lcsh:Q
business
human activities
Population Genetics
genetic susceptibility
Zdroj: PLoS ONE, Vol 9, Iss 6, p e100339 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: Objective: Adiponectin receptor 1 (encoded by ADIPOR1) is one of the major adiponectin receptors, and plays an important role in glucose and lipid metabolism. However, few studies have reported simultaneous associations between ADIPOR1 variants and type 2 diabetes (T2D), coronary artery disease (CAD) and T2D with CAD. Based on the "common soil" hypothesis, we investigated whether ADIPOR1 polymorphisms contributed to the etiology of T2D, CAD, or T2D with CAD in a Northern Han Chinese population. Methods: Our multi-disease comparison study enrolled 657 subjects, including 165 with T2D, 173 with CAD, 174 with both T2D and CAD (T2D+CAD), and 145 local healthy controls. Six ADIPOR1 single nucleotide polymorphisms (SNPs) were genotyped and their association with disease risk was analyzed. Results: Multi-case-control comparison identified two ADIPOR1 variants: rs3737884-G, which was simultaneously associated with an increased risk of T2D, CAD, and T2D+CAD (P-value range, 9.80×10-5-6.30×10-4; odds ratio (OR) range: 1.96-2.42) and 16850797-C, which was separately associated with T2D and T2D+CAD (P-value range: 0.007-0.014; OR range: 1.71-1.77). The risk genotypes of both rs3737884 and 16850797 were consistently associated with common metabolic phenotypes in all three diseases (P-value range: 4.81×10 -42-0.001). We observed an increase in the genetic dose-dependent cumulative risk with increasing risk allele numbers in T2D, CAD and T2D+CAD (Ptrend from 1.35×10-5-0.002). Conclusions: Our results suggest that ADIPOR1 risk polymorphisms are a strong candidate for the "common soil" hypothesis and could partially contribute to disease susceptibility to T2D, CAD, and T2D with CAD in the Northern Han Chinese population. © 2014 Jin et al.
Databáze: OpenAIRE
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