| Autor: |
Dezso Modos, Julia Scheel, Ralf Stephan, Piotr Gawron, Kristina Hanspers, Jean-Marie Ravel, Alexander Mazein, Corinna Montrone, Alberto Valdeolivas, Marek Ostaszewski, Susan L. Coort, Hiroaki Kitano, Tom C. Freeman, Vera Ortseifen, Vanessa Nakonecnij, M Orlic-Milacic, Jan Hasenauer, Veronica Shamovsky, Venkata P. Satagopam, Goar Frishman, M. Vazquez, D A B Rex, Miguel Ponce de Leon, Sylvain Soliman, Luana Licata, Ebru Kocakaya, Kinza Rian, Yusuke Hiki, Marton Olbei, Martina Kutmon, Bijay Jassal, Akira Funahashi, Lisa Matthews, Xiaoming Hu, Marcio Luis Acencio, Zsolt Bocskei, Robin Haw, Joaquín Dopazo, Agatha Treveil, Andrea Senff-Ribeiro, Tomáš Helikar, Chris T. Evelo, John A. Bachman, Julio Saez-Rodriguez, Takahiro G. Yamada, Emmanuel Barillot, Anton Yuryev, Bertrand De Meulder, Matti Hoch, Guanming Wu, Daniela Börnigen, Rudi Balling, Karen Rothfels, Pablo Porras, Hanna Borlinghaus, Andreas Dräger, Aurélien Naldi, Marta Iannuccelli, Leonard Schmiester, Dieter Maier, Jason E. Shoemaker, Valentin Grouès, Jakob Vanhoefer, Marius Rameil, Sara Sadat Aghamiri, Tobias Czauderna, Inna Kuperstein, Nhung Pham, Reinhard Schneider, Marina Esteban-Medina, Carole Goble, Benjamin M. Gyori, Emily E. Ackerman, Anita de Waard, Bhanwar Lal Puniya, Olaf Wolkenhauer, Alfonso Valencia, Julia Somers, Ewa Smula, Gisela Fobo, Robert Phair, Chris Sander, Laurent Heirendt, Carlos Vega, Jeremy Teuton, Emek Demir, Alina Renz, Tamas Korcsmaros, Vidisha Singh, Anastasia P. Nesterova, Andreas Ruepp, Lars M. T. Eijssen, Thawfeek M. Varusai, Aurelien Dugourd, Silvia Marchesi, Cristoffer Sevilla, Falk Schreiber, Barbara Brauner, Noriko Hiroi, Augustin Luna, Muying Wang, Shailendra K. Gupta, Egon Willighagen, Charles Auffray, Denise Slenter, Kristie L. Oxford, Franck Augé, Friederike Ehrhart, Muhammad Naveez, Stuart Owen, Arnau Montagud, Liam Fergusson, Enrico Glaab, Martin Golebiewski, Laurence Calzone, Alexander R. Pico, Dénes Türei, Marvin Martens, Henning Hermjakob, Rupert W. Overall, Jeremy Zucker, Özgün Babur, Gokce Yagmur Summak, Lincoln Stein, Anders Riutta, Anna Niarakis, Aurelio Orta-Resendiz, Francesca Sacco, Maria Peña-Chilet, Marta Conti, Jacques S. Beckmann, Angela Bauch |
| Přispěvatelé: |
University of Luxembourg [Luxembourg] |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Popis: |
We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the distributed development of its contents by a multi-faceted community of biocurators, domain experts, bioinformaticians, and computational biologists. We highlight the role of relevant databases and text mining approaches in the enrichment and validation of the curated mechanisms. We describe the contents of the Map and their relevance to the molecular pathophysiology of COVID-19 and the analytical and computational modelling approaches that can be applied for mechanistic data interpretation and predictions. We conclude by demonstrating concrete applications of our work through several use cases and highlight new testable hypotheses.; We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the distributed development of its contents by a multi-faceted community of biocurators, domain experts, bioinformaticians, and computational biologists. We highlight the role of relevant databases and text mining approaches in the enrichment and validation of the curated mechanisms. We describe the contents of the Map and their relevance to the molecular pathophysiology of COVID-19 and the analytical and computational modelling approaches that can be applied for mechanistic data interpretation and predictions. We conclude by demonstrating concrete applications of our work through several use cases and highlight new testable hypotheses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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