Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study
| Autor: | Joel R, Saper, David W, Dodick, Stephen D, Silberstein, Sally, McCarville, Mark, Sun, Peter J, Goadsby, Jack A, Klapper |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Migraine Disorders Intractable chronic migraine headache Stimulation Electric Stimulation Therapy Controlled studies law.invention occipital nerve stimulation headache days Chronic Migraine Randomized controlled trial Double-Blind Method law Medicine Humans Peripheral Nerves Lead (electronics) Chronic migraine headache business.industry Original Articles General Medicine Middle Aged Surgery Electrodes Implanted chronic migraine headache Anesthesia Chronic Disease Feasibility Studies Occipital nerve stimulation Female Neurology (clinical) Occipital nerve block device implantation business |
| Zdroj: | Cephalalgia |
| ISSN: | 1468-2982 |
| Popis: | Background: Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month. Methods: A multicenter, randomized, blinded, controlled feasibility study was conducted to obtain preliminary safety and efficacy data on occipital nerve stimulation (ONS) in CM. Eligible subjects received an occipital nerve block, and responders were randomized to adjustable stimulation (AS), preset stimulation (PS) or medical management (MM) groups. Results: Seventy-five of 110 subjects were assigned to a treatment group; complete diary data were available for 66. A responder was defined as a subject who achieved a 50% or greater reduction in number of headache days per month or a three-point or greater reduction in average overall pain intensity compared with baseline. Three-month responder rates were 39% for AS, 6% for PS and 0% for MM. No unanticipated adverse device events occurred. Lead migration occurred in 12 of 51 (24%) subjects. Conclusion: The results of this feasibility study offer promise and should prompt further controlled studies of ONS in CM. |
| Databáze: | OpenAIRE |
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