Two cases of hypothyroidism associated with alpha-interferon therapy
| Autor: | Kimio Nakanishi, Bunzo Matsuua, Masatake Tamai, Tsukasa Murakami, Toshikazu Masumoto, Yasuyuki Ohta, Shiro Noguchi, Morikazu Onji, Yoshiyasu Taniguchi, Junichi Tajiri |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Thyroid Gland Alpha interferon Adenocarcinoma medicine.disease_cause Gastroenterology Autoimmunity Hepatitis Immune system Hypothyroidism Internal medicine Internal Medicine medicine Humans Autoantibodies business.industry Thyroid Autoantibody Primary hypothyroidism Thyroiditis Autoimmune General Medicine medicine.disease Graves Disease Kidney Neoplasms Recombinant Proteins medicine.anatomical_structure Immunology Interferon Type I Female Thyroid function Viral hepatitis business |
| Zdroj: | Internal medicine (Tokyo, Japan). 31(3) |
| ISSN: | 0918-2918 |
| Popis: | Alpha-interferon was used for anti-cancer or anti-viral therapy in two patients with preexisting Autoimmune thyroid disease and in seven patients with chronic viral hepatitis who had no history of thyroid dysfunction. Primary hypothyroidism developed in the two patients who had a history of autoimmune thyroid disease, while no changes in thyroid function were observed in the other seven patients. Modulation of the immune system by alpha-interferon may have been responsible for the development of hypothyroidism in these two patients. Therefore, autoantibodies to the thyroid and the thyroid function should be assessed in patients undergoing alpha-interferon therapy.(Internal Medicine 31 : 373-376, 1992) |
| Databáze: | OpenAIRE |
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