β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging
| Autor: | Mrinmoy Maiti, Kai Kikuchi, K. K. Athul, Amandeep Kaur, Sankarprasad Bhuniya |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Carcinoma
Hepatocellular Liver Neoplasms Optical Imaging Metals and Alloys General Chemistry beta-Galactosidase Theranostic Nanomedicine Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Materials Chemistry Ceramics and Composites Humans Precision Medicine Fluorescent Dyes |
| Zdroj: | Chemical Communications. 58:6413-6416 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|