A Cisplatin-Selective Fluorescent Probe for Real-Time Monitoring of Mitochondrial Platinum Accumulation in Living Cells
| Autor: | Violet Eng Yee Lee, Hai Van Le, Wee Han Ang, Jun Xiang Ong |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
media_common.quotation_subject Cancer therapy chemistry.chemical_element Antineoplastic Agents Mitochondrion Catalysis medicine Humans media_common Fluorescent Dyes Cisplatin Optical Imaging General Chemistry General Medicine Prodrug Fluorescence Cell biology Mitochondria Spectrometry Fluorescence chemistry Platinum Intracellular medicine.drug HeLa Cells |
| Zdroj: | Angewandte Chemie (International ed. in English). 60(17) |
| ISSN: | 1521-3773 |
| Popis: | Mitochondria have emerged as important targets for cisplatin in cancer therapy. Apart from cisplatin, anticancer Pt complexes based on similar scaffolds have also been developed to target mitochondria. Yet cellular processing of cisplatin or these mitochondria-targeting Pt analogues remained unexplored, largely due to a lack of tools capable of probing these Pt drugs within an intracellular environment. We developed the first mitochondria-targeted fluorescent probe for real-time monitoring of Pt accumulation in mitochondria. We applied the probe to investigate mitochondria as cellular targets for Pt drug complexes and uncovered two distinct pathways whereby these Pt complexes could be delivered to mitochondria after cell entry. |
| Databáze: | OpenAIRE |
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