Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity

Autor: Kokoro Tsuzaki, Yoshiko Sano, Kazuhiko Kotani, Yoshinori Kitagawa, Taku Hamada, Makiko Yoshimura, Kahori Egawa, Chika Horikawa, Naoki Sakane, K. Saiga, Yoshinobu Kiso, N. Nagai, Toshio Moritani
Rok vydání: 2009
Předmět:
Zdroj: Journal of Endocrinological Investigation. 32:395-400
ISSN: 1720-8386
0391-4097
DOI: 10.1007/bf03346474
Popis: Background: In the adiponectin gene polymorphisms, single-nucleotide polymorphism (SNP)−45 and SNP276 have reportedly been associated with obesity, Type 2 diabetes, and other features of metabolic syndrome. Aim: Whether these adiponectin SNP affect obesity-related parameters during caloric restriction in obese subjects. Subjects and methods: Thirty-two obese Japanese women were treated by meal replacement with a low calorie diet for 8 weeks and asked to maintain their habitual lifestyle. Obesity-related parameters were measured before and after the treatment period. We determined four SNP (T45G, I164T, G276T, and C-11377G) using a fluorescent allele-specific DNA primer assay system and FRET probe assay system. Results: After the treatment, the extent of decrease in waist circumference was greater in the subjects with the G/G or G/T genotype of SNP276 than in those with the T/T genotype (p=0.026). As for SNP45, the extent of decrease in triglyceride levels was greater in the subjects with the T/T genotype than in those with the T/G genotype (p=0.003). For SNP-11377, the extent of decrease in systolic blood pressure and fasting plasma glucose was greater in the subjects with the C/G or G/G genotype than in those with the C/C genotype (p=0.044). Conclusion: Our findings indicate that each SNP in the adiponectin gene might modify the change in obesity-related parameters during meal replacement with a low calorie diet.
Databáze: OpenAIRE
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