Anti-inflammatory properties of rose oxide
| Autor: | Cristiane Flora Villarreal, Flavielle Martins de Melo, Danielle Gomes Santana, Milena Botelho Pereira Soares, Danielle Brustolim, Gisele Graça Leite dos Santos, Enilton A. Camargo, Damião Pergentino de Sousa, Fabiana Regina Nonato |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Leukocyte migration medicine.drug_class medicine.medical_treatment Acyclic Monoterpenes Interleukin-1beta Immunology Peritonitis Pharmacology Anti-inflammatory chemistry.chemical_compound Mice Cell Migration Assays Leukocyte medicine Animals Immunology and Allergy Rats Wistar Inflammation biology Anti-Inflammatory Agents Non-Steroidal Biological activity Rose oxide biology.organism_classification medicine.disease Rose oil Carrageenan Rats chemistry Gene Expression Regulation Essential oils Monoterpenes Cytokines Adjuvant |
| Zdroj: | International Immunopharmacology. 14(4):779-784 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2012.10.015 |
| Popis: | Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100 mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100 mg/kg) significantly reduced paw edema at 4, 6 and 24 h after the CFA injection. In addition, RO (100 mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25–100 mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4 h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25–100 mg/kg, 4 h after stimulus. In another experimental set, administration of RO (25–100 mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration. |
| Databáze: | OpenAIRE |
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