Anti-AT1R autoantibodies and prediction of the severity of Covid-19
| Autor: | Carla Cervelli, Franco Marinangeli, Anna Cecilia Carucci, Alessandro Grimaldi, Vincenza Cofini, Chiara Angeletti, Stefano Necozione, Franco Papola, Veronica Biancofiore, Alessia Rosciano |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Angiotensin II AT1R autoantibodies SARS-CoV-2 infection medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Short Communication Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Stimulation Autoantigens SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Gastroenterology Receptor Angiotensin Type 1 Internal medicine medicine Humans Immunology and Allergy Respiratory system AngII Angiotensin II Aged Autoantibodies Retrospective Studies Aged 80 and over Angiotensin II receptor type 1 SARS-CoV-2 business.industry Autoantibody COVID-19 General Medicine Middle Aged medicine.disease ACE-2 Angiotensin Converting Enzyme Hospitalization Italy Female business Cytokine storm AT1Rab autoantibodies direct vs Angiotensin II Receptor1 |
| Zdroj: | Human Immunology |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2021.10.006 |
| Popis: | The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6. This pro-inflammatory action stimulate the cytokine storm that characterizes the most severe forms of SARS-CoV-2 infection. We studied the effect of AT1Rab on the AT1R on 74 subjects with SARS-CoV-2 infection with respiratory symptoms requiring hospitalization. We divided the patients into 2 groups: 34 with moderate and 40 with severe symptoms that required ICU admission. Hospitalized subjects showed a 50% reduction in the frequency of AT1Rab compared to healthy reference population. Of the ICU patients, 33/40 (82.5%) were AT1Rab negative and 16/33 of them (48.5%) died. All 7 patients positive for AT1Rab survived. These preliminary data seem to indicate a protective role played by AT1R autoantibodies on inflammatory activation in SARS-CoV-2 infection pathology. |
| Databáze: | OpenAIRE |
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