Trypanocidal activity of abietane diterpenoids from the roots of Craniolaria annua
| Autor: | Graciela Troncone, Neudo Urdaneta, Diana Henríquez, Julio Herrera |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Chloroform
Stigmasterol Lamiaceae biology Cell Survival biology.organism_classification Plant Roots Trypanocidal Agents General Biochemistry Genetics and Molecular Biology Ferruginol chemistry.chemical_compound chemistry Biochemistry Spectrophotometry Abietanes Chlorocebus aethiops Vero cell Cytotoxic T cell Animals Trypanosoma cruzi Cytotoxicity Vero Cells Abietane |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences. 63(11-12) |
| ISSN: | 0939-5075 |
| Popis: | A chloroform extract from roots of Craniolaria annua provided six new C-11 unsubstituted abietanes, 14-hydroxy-6,12-dione-7,9(11),13-abietatriene (1), 14-hydroxy-12-oxo-7,9(11),13- abietatriene (2), 6,12,14-trihydroxyabieta-5,8,11,13-tetraen-7-one (3), ar-abietatriene-12-ol- 6,7-dione-14,16-oxide (4), ar-abietatriene-12,16-diol-14,16-oxide (5) and ar-abietatriene-12-ol- 7-one-14,16-oxide (6), and two known compounds, ferruginol and stigmasterol. The structures of both the new and known compounds were established by spectroscopic methods. Abietane 1 gave 14-hydroxy-6-oxoferruginol (1A) upon treatment with NaBH4. Abietanes 1, 1A, 3-5 and ferruginol showed cytotoxic effects against trypomastigote and epimastigote forms of Trypanosoma cruzi and against fibroblastic Vero cells. |
| Databáze: | OpenAIRE |
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