Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
| Autor: | Norbert Schuff, Antao Du, David Norman, Kristine Yaffe, D. L. Amend, M. W. Weiner, J. H. Kramer, Y. Y. Hsu, Mikko P. Laakso, William J. Jagust, Helena C. Chui, Bruce R Reed |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology Cephalometry Hippocampus Hippocampal formation Central nervous system disease Degenerative disease Alzheimer Disease Reference Values Internal medicine medicine Image Processing Computer-Assisted Entorhinal Cortex Humans Aged Aged 80 and over medicine.diagnostic_test Cognitive disorder Magnetic resonance imaging Middle Aged medicine.disease Entorhinal cortex Magnetic Resonance Imaging Psychiatry and Mental health Editorial Commentary Papers Cardiology Surgery Female Neurology (clinical) Alzheimer's disease Psychology Cognition Disorders Mental Status Schedule |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry. 71(4) |
| ISSN: | 0022-3050 |
| Popis: | Objectives—To explore volume changes of the entorhinal cortex (ERC) and hippocampus in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) compared with normal cognition (NC); to determine the powers of the ERC and the hippocampus for discrimination between these groups. Methods—This study included 40 subjects with NC, 36 patients with MCI, and 29 patients with AD. Volumes of the ERC and hippocampus were manually measured based on coronal T1 weighted MR images. Global cerebral changes were assessed using semiautomatic image segmentation. Results—Both ERC and hippocampal volumes were reduced in MCI (ERC 13%, hippocampus 11%, p |
| Databáze: | OpenAIRE |
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