Cellular accommodation and the response of bone to mechanical loading
| Autor: | Alexander G. Robling, Jennifer L. Schriefer, Stuart J. Warden, Leanne K. Saxon, Charles H. Turner |
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| Rok vydání: | 2004 |
| Předmět: |
Bone density
Osteoporosis Biomedical Engineering Biophysics Ulna Mechanotransduction Cellular Models Biological Stress (mechanics) Rats Sprague-Dawley Weight-Bearing Calcification Physiologic Negative feedback medicine Animals Orthopedics and Sports Medicine Bone formation Computer Simulation Mathematics Cell Proliferation Osteoblasts business.industry Rehabilitation Work (physics) Biomechanics Structural engineering medicine.disease Adaptation Physiological Rats Radiography Female Stress Mechanical business Accommodation Algorithms Biomedical engineering |
| Zdroj: | Journal of biomechanics. 38(9) |
| ISSN: | 0021-9290 |
| Popis: | Several mathematical rules by which bone adapts to mechanical loading have been proposed. Previous work focused mainly on negative feedback models, e.g., bone adapts to increased loading after a minimum strain effective (MES) threshold has been reached. The MES algorithm has numerous caveats, so we propose a different model, according to which bone adapts to changes in its mechanical environment based on the principle of cellular accommodation. With the new algorithm we presume that strain history is integrated into cellular memory so that the reference state for adaptation is constantly changing. To test this algorithm, an experiment was performed in which the ulnae of Sprague-Dawley rats were loaded in axial compression. The animals received loading for 15 weeks with progressively decreasing loads, increasing loads, or a constant load. The results showed the largest increases in geometry in the decreasing load group, followed by the constant load group. Bone formation rates (BFRs) were significantly greater in the decreasing load group during the first 2 weeks of the study as compared to all other groups (P |
| Databáze: | OpenAIRE |
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