Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model
| Autor: | Shohei Kasugai, Reo Ikumi, Norio Akino, Noriko Tachikawa, Takayuki Miyahara |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Poly l lactic acid Materials science Surface Properties Ultraviolet Rays Polyesters 02 engineering and technology 03 medical and health sciences 0302 clinical medicine Hydrophilic membrane Bone Density Materials Testing Animals Rats Wistar Bone regeneration General Dentistry Bone mineral Bone growth Guided Tissue Regeneration Skull Membranes Artificial X-Ray Microtomography 030206 dentistry 021001 nanoscience & nanotechnology Bone defect Rats Disease Models Animal Durapatite Membrane Ceramics and Composites Bone mineral content Collagen 0210 nano-technology Hydrophobic and Hydrophilic Interactions Biomedical engineering |
| Zdroj: | Dental Materials Journal. 37:912-918 |
| ISSN: | 1881-1361 0287-4547 |
| DOI: | 10.4012/dmj.2017-385 |
| Popis: | The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR. |
| Databáze: | OpenAIRE |
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