Circulating biomarkers for detection of ovarian cancer and predicting cancer outcomes
| Autor: | Daniel R. Budman, Iuliana Shapira, J.L. Lovecchio, C. Mason, Peter K. Gregersen, L. Dos Santos, Sharron Liang, Houman Khalili, Keith Sultan, J.S. Whyte, Annette Lee, Michaela Oswald, Tawfiqul Bhuiya, Mary Keogh, A.W. Menzin |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Pathology Adolescent Survival endocrine system diseases Carcinoma Ovarian Epithelial plasma miRNAs Young Adult prognostics Internal medicine microRNA Biomarkers Tumor diagnostics medicine Carcinoma Humans Neoplasm Neoplasms Glandular and Epithelial Young adult Molecular Diagnostics Aged Aged 80 and over Ovarian Neoplasms business.industry biomarkers Cancer Middle Aged medicine.disease female genital diseases and pregnancy complications MicroRNAs Serous fluid Circulating biomarkers Treatment Outcome ovarian cancer Female business Ovarian cancer |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2013.795 |
| Popis: | Background: Securing a diagnosis of ovarian cancer and establishing means to predict outcomes to therapeutics remain formidable clinical challenges. Early diagnosis is particularly important since survival rates are markedly improved if tumour is detected early. Methods: Comprehensive miRNA profiles were generated on presurgical plasma samples from 42 women with confirmed serous epithelial ovarian cancer, 36 women diagnosed with a benign neoplasm, and 23 comparably age-matched women with no known pelvic mass. Results: Twenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P |
| Databáze: | OpenAIRE |
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