Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation
| Autor: | Tariq Shafi, Xiaoqian Zhu, Seth T. Lirette, Andrew D. Rule, Thomas Mosley, Kenneth R. Butler, Michael E. Hall, Pradeep Vaitla, James J. Wynn, Maria Clarissa Tio, Neville R. Dossabhoy, Eliseo Guallar, Javed Butler |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of Internal Medicine. 175:1073-1082 |
| ISSN: | 1539-3704 0003-4819 |
| DOI: | 10.7326/m22-0610 |
| Popis: | Although the population-level differences between estimated glomerular filtration rate (eGFR) and measured glomerular filtration rate (mGFR) are well recognized, the magnitude and potential clinical implications of individual-level differences are unknown.To quantify the magnitude and consequences of the individual-level differences between mGFRs and eGFRs.Cross-sectional study.Four U.S. community-based epidemiologic cohort studies with mGFR.3223 participants in 4 studies.The GFRs were measured using urinary iothalamate and plasma iohexol clearance; the eGFR was calculated from serum creatinine concentration alone (eGFRThe participants' mean age was 59 years; 32% were Black, 55% were women, and the mean mGFR was 68. The population-level differences between mGFR and eGFRSingle measurement of mGFR and serum markers without short-term replicates.A substantial individual-level discrepancy exists between the mGFR and the eGFR. Laboratories reporting eGFR should consider including the extent of this uncertainty to avoid misinterpretation of eGFR as an mGFR replacement.National Institutes of Health. |
| Databáze: | OpenAIRE |
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