Silicone gel sheets relieve pain and pruritus with clinical improvement of keloid: possible target of mast cells
| Autor: | Fumihide Ogawa, Sang Jae Bae, Eishi K, Ichiro Katayama, Kazuhiro Shimizu, Hamasaki Y |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Administration Topical Pain Dermatology Severity of Illness Index Sampling Studies Statistics Nonparametric Muscle hypertrophy Silicone Gels chemistry.chemical_compound Silicone Keloid Antigen Biopsy medicine Humans Mast Cells Prospective Studies skin and connective tissue diseases Aged Pain Measurement Probability medicine.diagnostic_test business.industry Pruritus Biopsy Needle Middle Aged medicine.disease Mast cell Immunohistochemistry Surgery Treatment Outcome medicine.anatomical_structure chemistry Apoptosis Itching Female medicine.symptom business |
| Zdroj: | Journal of Dermatological Treatment. 14:248-252 |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546630310016808 |
| Popis: | Silicone gel sheet treatment is widely used to treat hypertrophic scars and keloids since it is easily applied and prevents scar pain and itching. We used Cica-Care silicone gel sheets in the conservative treatment of six patients for 24 weeks and recorded pain, itching, redness, and scar elevation every 4 weeks. We also investigated the number of mast cells and Fas antigen expression in the lesional skin (one patient) before and after treatment. The pain and itching clearly decreased after 4 weeks of the silicone gel sheeting and disappeared after 12 weeks. Twelve weeks were required for a reduction in scar redness and elevation. After 24 weeks, a decrease in the number of mast cells and the enhanced expression of Fas antigen by lesional fibroblasts were observed. Thus, silicone gel sheeting is effective and safe, especially with more severe symptoms of pain and itching possibly induced by mediators derived from increased mast cells. |
| Databáze: | OpenAIRE |
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