Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China
Autor: | Hongxue Meng, Ji Sun, Susheng Miao, Xionghui Mao, Jingshu Geng, Qingtao Shi, Qi You, Dongfeng Tan, Kexin Chen, Xiaomei Li, Jing He, Hongmei Wang, Lan-Lan Wei, Jiashi Geng, Guodong Yao, Huining Li, Fangjia Tong |
---|---|
Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine Oncology China medicine.medical_specialty Article Subject Concordance medicine.medical_treatment Oropharynx lcsh:Medicine General Biochemistry Genetics and Molecular Biology Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Biomarkers Tumor medicine Humans Stage (cooking) Papillomaviridae Risk factor Cyclin-Dependent Kinase Inhibitor p16 Aged General Immunology and Microbiology biology Histocytochemistry business.industry Papillomavirus Infections lcsh:R Cancer General Medicine Middle Aged biology.organism_classification medicine.disease Radiation therapy Oropharyngeal Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis Etiology Female Mouth Neoplasms business Research Article Cohort study |
Zdroj: | BioMed Research International, Vol 2018 (2018) BioMed Research International |
ISSN: | 2314-6141 2314-6133 |
Popis: | Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%) of the 1470 cases. HPV positive and p16 overexpression have a good concordance. However, we found that the etiological fraction of HPV in cancers of the OPSCCs was obviously lower in Northeast China than other cohorts previously reported. Interestingly, nearly 89% of patients with p16 expression were smokers, and nearly 70% of patients with p16 expression had a history of alcohol. Our study also demonstrates that p16 expression is significantly associated with early stage primary OPSCCs and the patients with p16 expression tend to show better survival following surgery and radiotherapy. |
Databáze: | OpenAIRE |
Externí odkaz: |