Adipogenesis and WNT signalling
| Autor: | Jaswinder K. Sethi, Constantinos Christodoulides, C Lagathu, Antonio Vidal-Puig |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Adipose tissue Biology Models Biological Article Paracrine signalling chemistry.chemical_compound Endocrinology Insulin resistance Internal medicine Adipocyte medicine Animals Humans Obesity Autocrine signalling beta Catenin Adipogenesis Mesenchymal stem cell Wnt signaling pathway Mesenchymal Stem Cells medicine.disease Cell biology PPAR gamma Wnt Proteins chemistry Inflammation Mediators Energy Metabolism Signal Transduction |
| Zdroj: | Trends in Endocrinology & Metabolism. 20:16-24 |
| ISSN: | 1043-2760 |
| Popis: | An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated. These regulatory factors mediate cross-talk between adipose cells, ensuring that adipocyte growth and differentiation are coupled to energy storage demands. The WNT family of autocrine and paracrine growth factors regulates adult tissue maintenance and remodelling and, consequently, is well suited to mediate adipose cell communication. Indeed, several recent reports, summarized in this review, implicate WNT signalling in regulating adipogenesis. Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications. |
| Databáze: | OpenAIRE |
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