Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood--a comparative ımmunohistochemical study
| Autor: | Hacı Ahmet Demir, Suna Emir, Esra Karakuş, Ayper Kaçar, Derya Özyörük, Resul Karakuş |
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| Rok vydání: | 2015 |
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Pathology medicine.medical_specialty medicine.drug_class Gene Expression Sarcoma Ewing Desmoplastic Small Round Cell Tumor Wilms Tumor Pathology and Forensic Medicine Neuroblastoma hemic and lymphatic diseases Rhabdomyosarcoma medicine Biomarkers Tumor Anaplastic lymphoma kinase Humans Neuroectodermal Tumors Primitive Anaplastic Lymphoma Kinase Carcinoma Small Cell Child business.industry Lymphoblastic lymphoma Receptor Protein-Tyrosine Kinases Wilms' tumor General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Neuroblastic Tumor Immunohistochemistry ALK inhibitor Child Preschool Female Sarcoma business |
| Zdroj: | Annals of diagnostic pathology. 19(4) |
| ISSN: | 1532-8198 |
| Popis: | The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma. Anaplastic lymphoma kinase protein expression in small round cell tumors of childhood is poorly described in the literature. The findings of our study highlight a potential and possible role of targeting ALK in pediatric solid tumors by using ALK immunohistochemistry. Anaplastic lymphoma kinase may also have an oncogenic role in rhabdomyosarcomas and peripheral neuroblastic tumors, and they may possibly be treated with ALK inhibitors. Anaplastic lymphoma kinase expression in Wilms tumors is not reported in the literature, previously. Our study evaluated ALK expression in Wilms tumor samples. (C) 2015 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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