A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
| Autor: | Thaddeus S. Stappenbeck, Nicole M. Koropatkin, Anna M. Seekatz, Gabriel Núñez, Vincent B. Young, Bernard Henrissat, Nicholas A. Pudlo, Nicolas Terrapon, Mahesh Desai, Arnaud Muller, Eric C. Martens, Sho Kitamoto, Christina A. Hickey, Nobuhiko Kamada, Mathis Wolter, Paul Wilmes |
|---|---|
| Přispěvatelé: | Architecture et fonction des macromolécules biologiques (AFMB), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Fonds National de la Recherche - FnR [sponsor] |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Dietary Fiber
Male 0301 basic medicine Microbiologie [F11] [Sciences du vivant] polysaccharides microbiome Mucin 2 Gut flora Mice fluids and secretions 0302 clinical medicine bacteroides Intestinal mucosa Enterobacteriaceae Infections/microbiology Microbiology [F11] [Life sciences] Intestinal Mucosa ComputingMilieux_MISCELLANEOUS 2. Zero hunger biology [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Structural Biology [q-bio.BM] Gastrointestinal Microbiome Enterobacteriaceae Infections dietary fiber Colitis [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] 3. Good health [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] Female 030211 gastroenterology & hepatology Disease Susceptibility Colon/microbiology Colon digestive system mucus layer General Biochemistry Genetics and Molecular Biology Microbiology 03 medical and health sciences mucin Intestinal Mucosa/microbiology microbiota Escherichia coli Animals Germ-Free Life Humans Microbiome Mucin-2 Mucin Akkermansia biology.organism_classification Mucus 030104 developmental biology Dietary Fiber/administration & dosage Citrobacter rodentium/physiology Immunology Mucin-2/genetics Citrobacter rodentium gylcans Colitis/microbiology |
| Zdroj: | Cell Cell, 2016, 167 (5), pp.1339+. ⟨10.1016/j.cell.2016.10.043⟩ Cell, Elsevier, 2016, 167 (5), pp.1339+. ⟨10.1016/j.cell.2016.10.043⟩ Cell, 167(5), 1339-1353.e21. United States (2016). |
| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/j.cell.2016.10.043⟩ |
| Popis: | Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric pathogens. We show that during chronic or intermittent dietary fiber deficiency, the gut microbiota resorts to host-secreted mucus glycoproteins as a nutrient source, leading to erosion of the colonic mucus barrier. Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium. Our work reveals intricate pathways linking diet, the gut microbiome, and intestinal barrier dysfunction, which could be exploited to improve health using dietary therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|