Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden
| Autor: | Ardeshir Ghavamzadeh, Ali Shahriari-Ahmadi, Zohreh Rahimi, Kamran Mansouri, Kamran Alimogaddam, Abbas Parsian, Mozafar Aznab, Mansour Rezaei, Hadi Mozafari |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Deep vein Iran Thrombophilia Gastroenterology Internal medicine medicine Factor V Leiden Humans Risk factor Venous Thrombosis biology business.industry Factor V Thrombosis Hematology General Medicine Odds ratio medicine.disease Surgery Venous thrombosis medicine.anatomical_structure Methylenetetrahydrofolate reductase Mutation biology.protein Female business |
| Zdroj: | Blood Coagulation & Fibrinolysis. 21:385-388 |
| ISSN: | 0957-5235 |
| Popis: | The aim of present study was to investigate the prevalence of factor V Leiden (FVL) c.1691G>A, prothrombin g.20210G>A and methylenetetrahydrofolate reductase (MTHFR) c.677C>T in deep vein thrombosis (DVT) patients and their possible association with DVT in western Iran. Eighty DVT patients with the mean age of 42.07 +/- 13.0 years including 44 women and 36 men and 100 sex-matched healthy individuals with the mean age of 37.63 +/- 13.3 years from Kermanshah Province of Iran with ethnic background of Kurd were studied for FVL c.1691G>A, prothrombin g.20210G>A and MTHFR c.677C>T by PCR-restriction fragment length polymorphism (RFLP) method using MnlI, HindIII and HinfI restriction enzymes, respectively. Prevalence of FVL was 11.4% in patients and 2% in control group. A significant association was found between FVL mutation and DVT with odds ratio (OR) of 6.3 [95% confidence interval (CI) = 1.32-30.05; P = 0.012]. The prevalence of prothrombin g.20210G>A variant in patients (3.8%) was nonsignificantly higher than control individuals (1.0%; OR 3.8; 95% CI = 0.39-37.81; P = 0.32). The prevalence of MTHFR c.677C>T in patients was 38.7% that was not statistically different from control group (44% P = 0.12). Venous thrombosis in legs was the most frequent clinical manifestation (n = 75), corresponding to 93.8% of the thromboembolism, followed by pulmonary thromboembolism (6.2%). We have, for the first time, determined the prevalence of inherited thrombophilia in a homogenous ethnic group of DVT patients and shown that FVL may be a risk factor for DVT in western Iran. |
| Databáze: | OpenAIRE |
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