Follow-up brain imaging of 37 children with congenital Zika syndrome : case series study
| Autor: | Natacha Calheiros de Lima Petribu, Marilia de Brito Abath, Roberto José Vieira de Mello, Arthur Cesário de Holanda, Maria de Fátima Viana Vasco Aragão, Alessandra Mertens Brainer-Lima, Luziany Carvalho Araújo, Paul M. Parizel, Maria do Carmo Menezes Bezerra Duarte, Vanessa van der Linden, Camila Sarteschi, Andrezza Fernandes, Patricia Jungmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Microcephaly Cerebral calcification Neuroimaging Zika virus White matter 03 medical and health sciences 0302 clinical medicine Pregnancy Calcinosis medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious biology business.industry Zika Virus Infection Research Infant Newborn Brain Infant Syndrome General Medicine Zika Virus medicine.disease biology.organism_classification White Matter medicine.anatomical_structure Female Human medicine Tomography X-Ray Computed business Brazil 030217 neurology & neurosurgery Follow-Up Studies Case series |
| Zdroj: | BMJ-BRITISH MEDICAL JOURNAL The BMJ |
| ISSN: | 1756-1833 |
| Popis: | OBJECTIVE To compare initial brain computed tomography (CT) scans with follow-up CT scans at one year in children with congenital Zika syndrome, focusing on cerebral calcifications. DESIGN Case series study. SETTING Barao de Lucena Hospital, Pernambuco state, Brazil. PARTICIPANTS 37 children with probable or confirmed congenital Zika syndrome during the microcephaly outbreak in 2015 who underwent brain CT shortly after birth and at one year follow-up. MAIN OUTCOME MEASURE Differences in cerebral calcification patterns between initial and follow-up scans. RESULTS 37 children were evaluated. All presented cerebral calcifications on the initial scan, predominantly at cortical-white matter junction. At follow-up the calcifications had diminished in number, size, or density, or a combination in 34 of the children (92%, 95% confidence interval 79% to 97%), were no longer visible in one child, and remained unchanged in two children. No child showed an increase in calcifications. The calcifications at the cortical-white matter junction which were no longer visible at follow-up occurred predominately in the parietal and occipital lobes. These imaging changes were not associated with any clear clinical improvements. CONCLUSION The detection of cerebral calcifications should not be considered a major criterion for late diagnosis of congenital Zika syndrome, nor should the absence of calcifications be used to exclude the diagnosis. |
| Databáze: | OpenAIRE |
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