Actual body weight-based vancomycin dosing in neonates
Autor: | Martin Šíma, Ondřej Slanař, Dick Tibboel, O. Černá, Pavla Pokorná, Karel Allegaert |
---|---|
Přispěvatelé: | Intensive Care, Pediatric Surgery, Pediatrics |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty genetic structures 030106 microbiology Therapeutic drug monitoring urologic and male genital diseases Body weight Sepsis 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Vancomycin medicine Humans Pharmacology (medical) Dosing Intensive care medicine Pharmacology medicine.diagnostic_test Critically ill business.industry Body Weight Infant Newborn Neonates biochemical phenomena metabolism and nutrition Nomogram Dosing nomogram medicine.disease Anti-Bacterial Agents Nomograms Infectious Diseases Oncology 030220 oncology & carcinogenesis Female Drug Monitoring business medicine.drug |
Zdroj: | Journal of Chemotherapy, 31(6), 307-312. Maney Publishing |
ISSN: | 1120-009X |
Popis: | This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill neonates and to propose an easy applicable dosing nomogram for initial treatment. Individual vancomycin pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a one-compartmental model. A linear regression model was used for examination of covariates. The mean (SD) volume of distribution (Vd) and clearance (CL) for vancomycin were 0.73 (0.31) L/kg and 0.052 (0.020) L/h/kg, respectively. Vd was related to actual body weight (ABW), gestational and postmenstrual age. CL was also associated with ABW, gestational, postmenstrual age and also creatinine clearance. ABW was the strongest predictor for vancomycin pharmacokinetics and consequently dosing. Loading dose (mg) of 11.81 × ABW (kg) + 7.86 and maintenance dose (mg/day) of 40.92 × ABW (kg) -22.18 most closely approximated pharmacokinetic target. Vancomycin pharmacokinetics was mainly influenced by ABW in neonates and a practical ABW-based dosing algorithm was developed. ispartof: JOURNAL OF CHEMOTHERAPY vol:31 issue:6 pages:307-312 ispartof: location:England status: published |
Databáze: | OpenAIRE |
Externí odkaz: |