Copper-induced changes of lipid peroxidation and hemato-biochemical parameters in rat blood: Protective role of flavonoids
| Autor: | M Jelena Mladenovic, S Zorica Saicic, G Milica Paunovic, S Veroljub Knezevic, Miloš M. Matić, S Andras Stajn, I Branka Ognjanovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Anemia chemistry.chemical_element hematological parameters Hematocrit General Biochemistry Genetics and Molecular Biology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Lactate dehydrogenase medicine heterocyclic compounds lcsh:QH301-705.5 030304 developmental biology 0303 health sciences medicine.diagnostic_test lipid peroxidation medicine.disease Rat blood Copper 3. Good health Endocrinology chemistry Biochemistry lcsh:Biology (General) 030220 oncology & carcinogenesis flavonoids biochemical parameters Hemoglobin erythrocyte General Agricultural and Biological Sciences Quercetin |
| Zdroj: | Archives of Biological Sciences, Vol 66, Iss 3, Pp 1271-1279 (2014) Archives of Biological Sciences |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | The effects of subchronic exposure to copper (Cu) on lipid peroxidation, hemato-biochemical parameters, and the possible protective role of flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar albino rats were treated with Cu (560 mg/L, p.o. as CuCl2 center dot 2H(2)O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each, i.p., every third day during the last 3 weeks) alone or in combination. Cu increased the concentration of lipid peroxides, decreased the number of erythrocytes, hemoglobin and hematocrit values and increased the activities of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin with Cu lowered the process of lipid peroxidation and restored examined hemato-biochemical parameters to control values. Our results indicate that Cu induced oxidative damage in erythrocytes, which led to anemia, while Quercetin and (-)-Epicatechin showed a protective effect on the hemato-biochemical processes in the blood of rats. Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173041] |
| Databáze: | OpenAIRE |
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