Androgen Receptor Alterations in Prostate Cancer Relapsed during a Combined Androgen Blockade by Orchiectomy and Bicalutamide
| Autor: | Pasi A. Koivisto, Marita Laurila, Eija-R. Hyytinen, Kyllikki Haapala, Mikko Roiha, Heikki Helin, Immo Rantala |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Bicalutamide medicine.drug_class Gene mutation Antiandrogen Pathology and Forensic Medicine Tosyl Compounds Prostate cancer Prostate Internal medicine Nitriles Humans Medicine Anilides Orchiectomy Molecular Biology business.industry Prostatic Neoplasms Androgen Antagonists Cell Biology medicine.disease Androgen Combined Modality Therapy Androgen receptor medicine.anatomical_structure Endocrinology Receptors Androgen Mutation Cancer research Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Laboratory Investigation. 81:1647-1651 |
| ISSN: | 0023-6837 |
| DOI: | 10.1038/labinvest.3780378 |
| Popis: | Mechanisms of prostate cancer (CaP) recurrence during a combined androgen blockade (CAB) are poorly understood. Previously, the role of androgen receptor (AR) gene mutations underlying the CAB therapy relapse has been raised. To investigate the hypothesis that AR gene aberrations are involved in CAB relapse, 11 locally recurrent CaP samples from patients treated with orchiectomy and bicalutamide were analyzed for copy number changes and DNA sequence alterations of the AR gene by fluorescence in situ hybridization and single-strand conformation polymorphism, respectively. Altogether, base changes were detected in four tumors (36%). Three of them were missense mutations (G166S, W741C, M749I) and two were silent polymorphisms. Interestingly, none of the tumors had AR amplification. These data suggest that different AR variants are developed and selected for during various types of hormonal treatments, and also, that CAB achieved by orchiectomy and bicalutamide does not act as a selective force for AR amplification. |
| Databáze: | OpenAIRE |
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