Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Autor: Yi Zhu, Donghong Zhang, Zhong-Ying Shen, Leijun Huo, Qingying Zhang, Li Zhou, Yi Zhang
Jazyk: angličtina
Předmět:
Oncology
Male
Cancer Research
Esophageal Neoplasms
Uterine Cervical Neoplasms
medicine.disease_cause
Polymerase Chain Reaction
Surgical oncology
Risk Factors
Prevalence
Medicine
Cervical cancer
Human papillomavirus 16
Human papillomavirus 18
Incidence (epidemiology)
Middle Aged
Viral Load
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunohistochemistry
Lymphatic Metastasis
Carcinoma
Squamous Cell
Female
Viral load
Oncovirus
Research Article
Adult
medicine.medical_specialty
China
lcsh:RC254-282
Risk Assessment
Young Adult
Internal medicine
Carcinoma
Genetics
Humans
Risk factor
neoplasms
Aged
Neoplasm Staging
Chi-Square Distribution
business.industry
Papillomavirus Infections
Oncogene Proteins
Viral
medicine.disease
digestive system diseases
Case-Control Studies
DNA
Viral
business
Carcinogenesis
Zdroj: BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 650 (2010)
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-650
Popis: Background Human papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal squamous-cell carcinoma (ESCC) has been reported repeatedly from Shantou, China, and other regions with a high incidence of esophageal carcinoma (EC). However, unlike in cervical squamous-cell carcinoma (CSCC), in ESCC, the characteristics of HPV are unclear. Thus, the role of high-risk HPV types in the carcinogenesis of ESCC remains uncertain. Methods Seventy cases of ESCC with 60 controls and 39 cases of CSCC with 54 controls collected from patients in Shantou region in China were compared for the distributions of HPV-16, -18 and -58; viral load; and viral integration using real-time PCR assay and HPV-16 expression using immunostaining. Results The detection rates and viral loads of HR-HPV infection were significantly lower in ESCC than in CSCC (50.0% vs. 79.48%, P = 0.005; 2.55 ± 3.19 vs. 361.29 ± 441.75, P = 0.002, respectively). The combined integration level of HPV-16, -18 and -58 was slightly lower in ESCC than in CSCC (P = 0.022). HPV-16 expression was detected in 59.26% of ESCC tissue and significantly associated with tumour grade (P = 0.027). Conclusions High levels of HR-HPV expression and integration may be an indicator of the risk of ESCC, at least for patients in the Shantou region of China. However, a relatively low HPV copy number and infection rate in ESCC is unlikely to play an essential a role in the carcinogenesis of ESCC as in cervical cancer. Factors other than HR-HPV infection may contribute to the carcinogenesis of ESCC.
Databáze: OpenAIRE
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