Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study
Autor: | Yi Zhu, Donghong Zhang, Zhong-Ying Shen, Leijun Huo, Qingying Zhang, Li Zhou, Yi Zhang |
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Jazyk: | angličtina |
Předmět: |
Oncology
Male Cancer Research Esophageal Neoplasms Uterine Cervical Neoplasms medicine.disease_cause Polymerase Chain Reaction Surgical oncology Risk Factors Prevalence Medicine Cervical cancer Human papillomavirus 16 Human papillomavirus 18 Incidence (epidemiology) Middle Aged Viral Load lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunohistochemistry Lymphatic Metastasis Carcinoma Squamous Cell Female Viral load Oncovirus Research Article Adult medicine.medical_specialty China lcsh:RC254-282 Risk Assessment Young Adult Internal medicine Carcinoma Genetics Humans Risk factor neoplasms Aged Neoplasm Staging Chi-Square Distribution business.industry Papillomavirus Infections Oncogene Proteins Viral medicine.disease digestive system diseases Case-Control Studies DNA Viral business Carcinogenesis |
Zdroj: | BMC Cancer BMC Cancer, Vol 10, Iss 1, p 650 (2010) |
ISSN: | 1471-2407 |
DOI: | 10.1186/1471-2407-10-650 |
Popis: | Background Human papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal squamous-cell carcinoma (ESCC) has been reported repeatedly from Shantou, China, and other regions with a high incidence of esophageal carcinoma (EC). However, unlike in cervical squamous-cell carcinoma (CSCC), in ESCC, the characteristics of HPV are unclear. Thus, the role of high-risk HPV types in the carcinogenesis of ESCC remains uncertain. Methods Seventy cases of ESCC with 60 controls and 39 cases of CSCC with 54 controls collected from patients in Shantou region in China were compared for the distributions of HPV-16, -18 and -58; viral load; and viral integration using real-time PCR assay and HPV-16 expression using immunostaining. Results The detection rates and viral loads of HR-HPV infection were significantly lower in ESCC than in CSCC (50.0% vs. 79.48%, P = 0.005; 2.55 ± 3.19 vs. 361.29 ± 441.75, P = 0.002, respectively). The combined integration level of HPV-16, -18 and -58 was slightly lower in ESCC than in CSCC (P = 0.022). HPV-16 expression was detected in 59.26% of ESCC tissue and significantly associated with tumour grade (P = 0.027). Conclusions High levels of HR-HPV expression and integration may be an indicator of the risk of ESCC, at least for patients in the Shantou region of China. However, a relatively low HPV copy number and infection rate in ESCC is unlikely to play an essential a role in the carcinogenesis of ESCC as in cervical cancer. Factors other than HR-HPV infection may contribute to the carcinogenesis of ESCC. |
Databáze: | OpenAIRE |
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