Neurological Soft Signs Are Associated With Altered Cerebellar-Cerebral Functional Connectivity in Schizophrenia
| Autor: | Jia Huang, Karen S. Y. Hung, Eric F.C. Cheung, Raymond C.K. Chan, Yong-ming Wang, Arne Møller, Yi Wang, Ya Wang, Simon S.Y. Lui, Han-yu Zhou, Xin-lu Cai, Henry K.F. Mak, Pak C. Sham |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Adult Cerebellum Cerebral Cortex/diagnostic imaging Precuneus Inferior frontal gyrus cerebellar-cerebral connectivity behavioral disciplines and activities Cerebellum/diagnostic imaging Young Adult 03 medical and health sciences 0302 clinical medicine Inferior temporal gyrus mental disorders Connectome medicine Humans Cerebral Cortex business.industry functional connectivity Schizophrenia/diagnostic imaging medicine.disease Magnetic Resonance Imaging 030227 psychiatry schizophrenia Psychiatry and Mental health neurological soft signs medicine.anatomical_structure nervous system Superior frontal gyrus Cerebral cortex Schizophrenia Endophenotype Female business Neuroscience 030217 neurology & neurosurgery Regular Articles |
| Zdroj: | Cai, X L, Wang, Y M, Wang, Y, Zhou, H Y, Huang, J, Wang, Y, Lui, S S Y, Møller, A, Hung, K S Y, Mak, H K F, Sham, P C, Cheung, E F C & Chan, R C K 2021, ' Neurological Soft Signs Are Associated with Altered Cerebellar-Cerebral Functional Connectivity in Schizophrenia ', Schizophrenia Bulletin, vol. 47, no. 5, pp. 1452-1462 . https://doi.org/10.1093/schbul/sbaa200 Schizophr Bull |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/sbaa200 |
| Popis: | Cerebellar dysfunction is associated with neurological soft signs (NSS), which is a promising endophenotype for schizophrenia spectrum disorders. However, the relationship between cerebellar-cerebral resting-state functional connectivity (rsFC) and NSS is largely unexplored. Moreover, both NSS and cerebellar-cerebral rsFC have been found to be correlated with negative symptoms of schizophrenia. Here, we investigated the correlations between NSS and cerebellar-cerebral rsFC, explored their relationship with negative symptoms in a main dataset, and validated the significant findings in a replication dataset. Both datasets comprised schizophrenia patients and healthy controls. In schizophrenia patients, we found positive correlations between NSS and rsFC of the cerebellum with the inferior frontal gyrus and the precuneus, and negative correlations between NSS and rsFC of the cerebellum with the inferior temporal gyrus. In healthy controls, NSS scores were positively correlated with rsFC of the cerebellum with the superior frontal gyrus and negatively correlated with rsFC between the cerebellum and the middle occipital gyrus. Cerebellar-prefrontal rsFC was also positively correlated with negative symptoms in schizophrenia patients. These findings were validated in the replication dataset. Our results suggest that the uncoupling of rsFC between the cerebellum and the cerebral cortex may underlie the expression of NSS in schizophrenia. NSS-related cerebellar-prefrontal rsFC may be a potential neural pathway for possible neural modulation to alleviate negative symptoms. |
| Databáze: | OpenAIRE |
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