Emerging Mechanisms by which EMT Programs Control Stemness
| Autor: | Molly M. Wilson, Jacqueline A. Lees, Robert A. Weinberg, Vincent J. Guen |
|---|---|
| Přispěvatelé: | Massachusetts Institute of Technology (MIT), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Fondation ARC pour la Recherche sur le Cancer, Cancéropôle Grand Ouest, Université de Rennes 1, Fondation MIT, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
cancer stem cells Cancer Research Epithelial-Mesenchymal Transition Carcinogenesis [SDV]Life Sciences [q-bio] Tumor cells Antineoplastic Agents [SDV.CAN]Life Sciences [q-bio]/Cancer Biology medicine.disease_cause Epigenesis Genetic 03 medical and health sciences stemness 0302 clinical medicine Cancer stem cell Neoplasms medicine Humans Asymmetric Cell Division EMT Cellular Reprogramming 3. Good health Gene Expression Regulation Neoplastic Adult Stem Cells 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research Neoplastic Stem Cells Neoplasm Recurrence Local Adult stem cell |
| Zdroj: | Trends in Cancer Trends in Cancer, 2020, 6 (9), pp.775-780. ⟨10.1016/j.trecan.2020.03.011⟩ Trends in Cancer, Cell Press, 2020, 6 (9), pp.775-780. ⟨10.1016/j.trecan.2020.03.011⟩ |
| ISSN: | 2405-8033 |
| DOI: | 10.1016/j.trecan.2020.03.011⟩ |
| Popis: | International audience; Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain cancers depends on a subset of tumor cells, called cancer stem cells (CSCs), with SC-like properties. In addition to being responsible for tumorigenesis, CSCs exhibit elevated resistance to therapy and thus drive tumor relapse post-treatment. The epithelial-mesenchymal transition (EMT) programs promote SC and CSC stemness in many epithelial tissues. Here, we provide an overview of the mechanisms underlying the relationship between stemness and EMT programs, which may represent therapeutic vulnerabilities for the treatment of cancers. |
| Databáze: | OpenAIRE |
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