Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART
| Autor: | Andrea Cossarizza, Ivano Mezzaroma, Antonella Isgrò, Caterina Fimiani, Giuseppe Luzi, Fernando Aiuti, Antonella Esposito, Wladimiro DeSantis, Marcello Pinti, Wilma Leti, Marco Marziali |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Adult CD4-Positive T-Lymphocytes Male Stromal cell Fas Ligand Protein HAART Naive T cell T cell HIV Infections CD4 Tcells Fas ligand Bone Marrow Antiretroviral Therapy Highly Active medicine Humans fas Receptor Progenitor cell Clonogenic assay Aged business.industry Tumor Necrosis Factor-alpha Interleukin-7 Lymphopoiesis HIV Middle Aged Viral Load Hematopoietic Stem Cells HIV HAART CD4 Tcells CD4 Lymphocyte Count Infectious Diseases medicine.anatomical_structure Immunology HIV-1 Interleukin-2 RNA Viral Female Bone marrow Stromal Cells business CD8 |
| Popis: | BACKGROUND Inflammatory cytokines in bone marrow may impair hematolymphopoiesis in human immunodeficiency virus (HIV)-infected subjects who do not experience reconstitution of CD4(+) T cells despite suppression of virus replication while receiving highly active antiretroviral therapy (HAART) (immunological nonresponders). METHODS Bone marrow samples from 12 immunological nonresponders receiving HAART were studied and compared with samples from 11 immunological responders. The mean CD4(+) T cell count (+/- standard deviation) was 174 +/- 68 cells/mm(3) and plasma HIV RNA levels had been |
| Databáze: | OpenAIRE |
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