Nitric oxide-releasing sol–gels as antibacterial coatings for orthopedic implants
| Autor: | Aaron R. Rothrock, Mark H. Schoenfisch, Brian J. Nablo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Staphylococcus aureus
Materials science Biophysics Bioengineering Nitric Oxide medicine.disease_cause Bacterial Adhesion No donors Nitric oxide Biomaterials chemistry.chemical_compound Coated Materials Biocompatible Staphylococcus epidermidis Diamine medicine Cell adhesion Sol-gel biology fungi Metallurgy technology industry and agriculture Prostheses and Implants Adhesion Stainless Steel biology.organism_classification Anti-Bacterial Agents Microscopy Fluorescence chemistry Mechanics of Materials Pseudomonas aeruginosa Ceramics and Composites Gels Nuclear chemistry |
| Zdroj: | Biomaterials. 26:917-924 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2004.03.031 |
| Popis: | To assess the benefits of nitric oxide (NO)-releasing sol-gels as potential antibacterial coatings for orthopedic devices, medical-grade stainless steel is coated with a sol-gel film of 40% N-aminohexyl-N-aminopropyltrimethoxysilane and 60% isobutyltrimethoxysilane. Upon converting the diamine groups in these films to diazeniumdiolate NO donors, the NO release from the sol-gel-coated stainless steel is evaluated at both ambient and physiological temperature. Sol-gel films incubated at 25 degrees C have a lower NO flux over the first 24 h compared to those at 37 degrees C, but release more than five times longer. The bacterial adhesion resistance of NO-releasing coatings is evaluated in vitro by exposing bare steel, sol-gel, and NO-releasing sol-gel-coated steel to cell suspensions of Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis at 25 degrees C and 37 degrees C. Cell adhesion to bare and sol-gel-coated steel is similar, while NO-releasing surfaces have significantly less bacterial adhesion for all species and temperatures investigated. |
| Databáze: | OpenAIRE |
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