PD-L1 CPS Scoring Accuracy in Small Biopsies and Aspirate Cell Blocks from Patients with Head and Neck Squamous Cell Carcinoma
| Autor: | Ajit S Paintal, Bruce Brockstein |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Biopsy B7-H1 Antigen Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine PD-L1 medicine Biomarkers Tumor Humans Cell block Aged Aged 80 and over Original Paper medicine.diagnostic_test biology business.industry Squamous Cell Carcinoma of Head and Neck Gold standard (test) Middle Aged medicine.disease Head and neck squamous-cell carcinoma Immunohistochemistry 030104 developmental biology Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Oral and maxillofacial surgery biology.protein Female Radiology business |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| Popis: | To evaluate the performance characteristics of PD-L1 immunohistochemistry (IHC) combined positive scoring (CPS) in core biopsies and aspirate cell blocks from patients with head and neck squamous cell carcinoma (HNSqCCa). PD-L1 IHC using the SP263 antibody was performed on 20 paired cases which consisted of a small biopsy and an excisional specimen. The scores were compared at both the 1% and 20% cutpoints. Using the CPS result obtained from the resected specimen or excisional biopsy as the gold standard, PD-L1 IHC performed on the core biopsy or cell block identified 4 of 6 positive cases (66%) at the 20% cutpoint and 12 of 17 (70%) positive patients at the 1% cutpoint. False positive cases were uncommon at both cutpoints. CPS scoring should be used with caution in small biopsies from patients with HNSqCCa. A negative result should prompt consideration of an excisional biopsy and repeat testing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink