Periodic variation in R-R intervals and cardiovascular autonomic regulation in young adult Syrian hamsters
| Autor: | Marc Fiszman, André Salmon, Yves Fromes, Heloise Mongue-Din |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Atropine
Aging medicine.medical_specialty Physiology Adrenergic beta-Antagonists Hamster Biology Autonomic Nervous System Autonomic regulation Cardiovascular Physiological Phenomena Electrocardiography Heart Rate Cricetinae Physiology (medical) Internal medicine Heart rate medicine Animals Heart rate variability Statistical analysis Young adult Syrian hamsters Mesocricetus Isoproterenol Adrenergic beta-Agonists medicine.disease Propranolol Endocrinology Echocardiography Heart failure Cardiology Anti-Arrhythmia Agents |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R610-R617 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.90376.2008 |
| Popis: | Several hamster strains are commonly used as models for cardiomyopathic phenotypes evolving toward heart failure. However, little is known about heart rate variability (HRV) in this species. Prolonged surface ECG recording, a prerequisite to HRV studies, can be obtained either by telemetry or by restraints. Here, we performed long time ECG recording using telemetry on young adult Syrian hamsters and we analyzed time series of interbeat intervals. Standard statistics showed that the mean of normal R-R intervals slightly increased with age, with standard deviation of normal R-R intervals remaining stable over time. However, time domain analysis using Poincaré plots revealed dynamic changes in the HRV. Analysis of frequency domains revealed that the ratio of spectral components (low frequency/high frequency) exhibited a maturation pattern. Thus refined analysis of HRV revealed a more complex pattern than common statistical analysis would translate. Unlike other rodents, hamsters display a great spontaneous variability of their heart rate. As the complexity canvas of HRV might be the consequence of extracardiac regulation factors, we assessed the sympathovagal balance in both time and frequency domain of heart rate. Pharmacological tests revealed that both sympathetic and vagal tones contribute to HRV in Syrian hamsters. Thus Syrian hamsters have a broad intrinsic HRV with large influences of the neurovegetative system. However, the influence of the previous beat seems to prevail over the autonomic oscillators. These animals present a high sensitivity to artificially altered cardiac regulation and might be great models for the diagnosis of early alterations in the HRV related to pathology. Therefore, Syrian hamsters represent a unique model for HRV studies. |
| Databáze: | OpenAIRE |
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