Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila
| Autor: | Tony D. Southall, Jessica Perochon, André B. Medina, Gabriel N. Aughey, Yachuan Yu, Julia B. Cordero |
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| Přispěvatelé: | Wellcome Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
HYPOXIA
Biology Fibroblast growth factor Article 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Animals Homeostasis Regeneration ENCODES Intestinal Mucosa Stem Cell Niche 11 Medical and Health Sciences Tissue homeostasis 030304 developmental biology 0303 health sciences Science & Technology BHLH-PAS PROTEIN Stem Cells Regeneration (biology) MIDGUT PROLIFERATION RNA-Binding Proteins Cell Biology 06 Biological Sciences GENE Adaptation Physiological Intestinal epithelium Cell biology HOMOLOG Adult Stem Cells Crosstalk (biology) BACTERIAL-INFECTION Fibroblast growth factor receptor 030220 oncology & carcinogenesis Drosophila Stem cell MESSENGER-RNA Life Sciences & Biomedicine Developmental Biology Signal Transduction |
| Zdroj: | Nature cell biology |
| ISSN: | 1476-4679 1465-7392 |
| Popis: | Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here we uncover a previously unrecognised crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration. Following damage to the intestinal epithelium, gut-derived reactive oxygen species activate tracheal HIF-1α and bidirectional FGF/FGFR signalling, leading to reversible remodelling of gut-associated terminal tracheal cells and intestinal stem cell proliferation following damage. Unexpectedly, reactive oxygen species-induced adult tracheal plasticity involves downregulation of the tracheal specification factor trachealess (trh) and upregulation of IGF2 messenger RNA-binding protein (IGF2BP2/Imp). Our results reveal an intestine–vasculature inter-organ communication programme that is essential to adapt the stem cell response to the proliferative demands of the intestinal epithelium. |
| Databáze: | OpenAIRE |
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