Synthesis variants of quaternary ammonium polyethyleneimine nanoparticles and their antibacterial efficacy in dental materials
| Autor: | Ervin I. Weiss, Nathan Zaltsman, Nurit Beyth, Dana Kesler-Shvero |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Resin composite Enterococcus faecium Biomedical Engineering Biophysics Nanoparticle Bioengineering 02 engineering and technology Antibacterial efficacy Bacterial growth Biomaterials 03 medical and health sciences chemistry.chemical_compound Dental Materials 0302 clinical medicine Organic chemistry Polyethyleneimine Ammonium biology 030206 dentistry General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Anti-Bacterial Agents Quaternary Ammonium Compounds chemistry Nanoparticles 0210 nano-technology Antibacterial activity |
| Zdroj: | Journal of applied biomaterialsfunctional materials. 14(2) |
| ISSN: | 2280-8000 |
| Popis: | Resin-based dental materials allow bacterial growth on their surface and lack antibacterial activity, leading to functional and esthetic failure. Quaternary ammonium polyethyleneimine (QPEI) nanoparticles (NPs) incorporated in resin-based composite at 2% wt/wt have demonstrated prolonged and complete inhibition of bacterial growth. This study focused on optimization of QPEI NP synthesis to reduce the concentration required for bacterial growth inhibition. The objective here was to enhance antimicrobial efficacy by excess base neutralization, using phosphoric or hydrochloric acid, and by using surfactants.QPEI NP variants were prepared (i) under controlled neutralization of acid, using NaHCO3, (ii) under controlled carbonate ion neutralization with HCl or H3PO4 and (iii) by treatment with N-lauroylsarcosine or glycerol monostearate. NPs incorporated in the dental materials were examined for their antibacterial effect against Enterococcus faecalis.Controlled addition of NaHCO3 resulted in modified QPEI NPs with an increased ability to inhibit bacterial growth. Surface treatment with N-lauroylsarcosine resulted in enhanced antibacterial activity at 0.5% wt/wt concentration in acrylate and epoxy resin-based dental materials.The antimicrobial efficacy of QPEI NP may be improved significantly by controlling the addition of NaHCO3, neutralization of excess base and the surface-agent effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|