Risk of relapse phenotype recurrence in multiple sclerosis
| Autor: | Daniele Spitaleri, Joseph Herbert, Jeannette Lechner-Scott, Bhim Singhal, Tomas Kalincik, Carmen Adella Sirbu, Maria Edite Rio, Marc Girard, Celia Oreja-Guevara, Norbert Vella, Pierre Duquette, Raymond Hupperts, Francois Grand'Maison, Vincent Van Pesch, Alessandra Lugaresi, Maria Pia Amato, Raed Alroughani, Thor Petersen, Marcela Fiol, Gerardo Iuliano, Steve Vucic, Giorgio Giuliani, Ricardo Fernandez-Bolanos, Guillermo Izquierdo, Tatjana Petkovska-Boskova, Freek Verheul, Michael Barnett, Helmut Butzkueven, Mark Paine, Maria Laura Saladino, Jose Antonio Cabrera-Gomez, Erik van Munster, Maria Trojano, Roberto Bergamaschi, S. Flechter, Danny Liew, Orla Gray, Katherine Buzzard, Edgardo Cristiano, Cavit Boz, Mark Slee, Cameron Shaw, Aldo Savino, Vilija Jokubaitis, Csilla Rozsa, Fraser Moore, Pierre Grammond, John Parratt |
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| Přispěvatelé: | MUMC+: MA Med Staf Spec Neurologie (9), Klinische Neurowetenschappen, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Kalincik T, Buzzard K, Jokubaitis V, Trojano M, Duquette P, Guillermo I, Girard M, Lugaresi A, Grammond P, Grand'maison F, Oreja-Guevara C, Boz C, Hupperts R, Petersen T, Giuliani G, Iuliano G, Lechner-Scott J, Barnett M, Bergamaschi R, Van Pesch V, Amato MP, van Munster E, Fernandez-Bolanos R, Verheul F, Fiol M, Cristiano E, Slee M, Rio ME, Spitaleri D, Alroughani R, Gray O, Saladino ML, Flechter S, Herbert J, Cabrera-Gomez JA, Vella N, Paine M, Shaw C, Moore F, Vucic S, Savino A, Singhal B, Petkovska-Boskova T, Parratt J, Sirbu CA, Rozsa C, Liew D, Butzkueven H, on behalf of the MSBase Study Group |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty phenotype Disease Logistic regression MSBase Multiple sclerosis Disability Evaluation Multiple Sclerosis Relapsing-Remitting Recurrence Internal medicine medicine Humans multiple sclerosis relapse symptom prognosis Aged business.industry Age Factors presentation of neurological diseases Middle Aged medicine.disease Phenotype Natural history Institutional repository Neurology Immunology Disease Progression Female Observational study prognosis Neurology (clinical) business Progressive disease |
| Zdroj: | Multiple Sclerosis Journal, 20(11), 1511-1522. SAGE Publications Ltd Kalincik, T, Buzzard, K, Jokubaitis, V, Trojano, M, Duquette, P, Guillermo, I, Girard, M, Lugaresi, A, Grammond, P, Grand'maison, F, Oreja-Guevara, C, Boz, C, Hupperts, R, Petersen, T, Giuliani, G, Iuliano, G, Lechner-Scott, J, Barnett, M, Bergamaschi, R, Van Pesch, V, Amato, M P, van Munster, E, Fernandez-Bolanos, R, Verheul, F, Fiol, M, Cristiano, E, Slee, M, Rio, M E, Spitaleri, D, Alroughani, R, Gray, O, Saladino, M L, Flechter, S, Herbert, J, Cabrera-Gomez, J A, Vella, N, Paine, M, Shaw, C, Moore, F, Vucic, S, Savino, A, Singhal, B, Petkovska-Boskova, T, Parratt, J, Sirbu, C-A, Rozsa, C, Liew, D, Butzkueven, H & on behalf of the MSBase Study Group 2014, ' Risk of relapse phenotype recurrence in multiple sclerosis ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 20, no. 11, pp. 1511-1522 . https://doi.org/10.1177/1352458514528762 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458514528762 |
| Popis: | Objectives: The aim was to analyse risk of relapse phenotype recurrence in multiple sclerosis and to characterise the effect of demographic and clinical features on this phenotype. Methods: Information about relapses was collected using MSBase, an international observational registry. Associations between relapse phenotypes and history of similar relapses or patient characteristics were tested with multivariable logistic regression models. Tendency of relapse phenotypes to recur sequentially was assessed with principal component analysis. Results: Among 14,969 eligible patients (89,949 patient-years), 49,279 phenotypically characterised relapses were recorded. Visual and brainstem relapses occurred more frequently in early disease and in younger patients. Sensory relapses were more frequent in early or non-progressive disease. Pyramidal, sphincter and cerebellar relapses were more common in older patients and in progressive disease. Women presented more often with sensory or visual symptoms. Men were more prone to pyramidal, brainstem and cerebellar relapses. Importantly, relapse phenotype was predicted by the phenotypes of previous relapses. (OR = 1.8–5, p = 10-14). Sensory, visual and brainstem relapses showed better recovery than other relapse phenotypes. Relapse severity increased and the ability to recover decreased with age or more advanced disease. Conclusion: Relapse phenotype was associated with demographic and clinical characteristics, with phenotypic recurrence significantly more common than expected by chance. |
| Databáze: | OpenAIRE |
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