Association of angiotensin II type 1 receptor gene A1166C polymorphism with the presence of diabetes mellitus and metabolic syndrome in patients with documented coronary artery disease
| Autor: | Mohammadreza Oladi, Shima Tavallaie, Mohsen Moohebati, Jamal Kasaian, Amirhossein Sahebkar, Habib Allah Esmaeili, Gordon A. Ferns, Akram Assali, Mitra Hassani, Javad Behravan, Shahireh Omidvar Tehrani, Farnoosh Tatari, Majid Ghayour-Mobarhan, Roghayeh Paydar |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Genotype Single-nucleotide polymorphism Coronary Artery Disease Coronary Angiography Polymerase Chain Reaction Receptor Angiotensin Type 1 Gene Frequency Polymorphism (computer science) Diabetes mellitus Internal medicine Internal Medicine medicine Prevalence Humans Genetic Predisposition to Disease Sex Distribution Allele frequency Metabolic Syndrome business.industry Middle Aged medicine.disease Angiotensin II Endocrinology Diabetes Mellitus Type 2 Female Gene polymorphism Metabolic syndrome business Polymorphism Restriction Fragment Length |
| Zdroj: | European journal of internal medicine. 22(3) |
| ISSN: | 1879-0828 |
| Popis: | BACKGROUND There are relatively limited data available on the genetic susceptibility to diabetes mellitus and metabolic syndrome in the Iranian population. We have therefore investigated the association between the angiotensin II type I receptor gene polymorphism (AT(1)R/A1166C) and the presence of diabetes mellitus and metabolic syndrome in a well defined group of patients METHODS Patients with angiographically defined coronary artery disease (CAD) (n=309) were evaluated for the presence of AT(1)R/A1166C polymorphism. These patients were classified into subgroups with (n=164, M/F: 109/55) and without (n=145, M/F: 84/61) diabetes mellitus. The AT(1)R polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) based method. RESULTS There was a higher frequency of polymorphic genotypes (AC+CC) in the diabetic compared with the non-diabetic group (p=0.01). When determined for each gender separately, this difference remained significant in the males (p=0.04) but not in females (p=0.09). With regard to the allele frequencies, the C allele was significantly higher and the A allele frequency was lower in the diabetic group (p=0.01). This remained significant after gender segregation for males (p=0.01) but not females. In the binary logistic regression analysis, only serum fasting glucose was found as the independent predictor for the presence of diabetes in the CAD patients (β=1.16, p |
| Databáze: | OpenAIRE |
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