Effect of Rooperol on Collagen Synthesis and Cell Growth
| Autor: | Carl F. Albrecht, M. Iqbal Parker, E. Dietzsch |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Clinical Biochemistry
Catechols Biochemistry Metastasis Cell Line Antimetastatic Agent medicine Genetics Humans Cyclooxygenase Inhibitors Lung Molecular Biology Skin Cell invasion Cell growth Chemistry Cancer Cell Biology Fibroblasts medicine.disease Cell biology Cell culture Collagen Normal skin Type I collagen Cell Division |
| Zdroj: | International Union of Biochemistry and Molecular Biology: Life. 48:321-325 |
| ISSN: | 1521-6551 1521-6543 |
| DOI: | 10.1080/152165499307044 |
| Popis: | The effect of rooperol on type I collagen synthesis in normal skin and lung fibroblasts and cell growth in normal and transformed fibroblasts was investigated. Low concentrations of rooperol selectively inhibited the growth of transformed cells while stimulating collagen synthesis in normal fibroblasts. Elevated collagen synthesis and deposition could impede tumour cell invasion and metastasis, implying that rooperol may be useful as an antimetastatic agent in the treatment of cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text