A new oxisuran metabolite
| Autor: | R. Clive Greenough, Frederick J. Di Carlo, Franz-Josef Leinweber |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Chromatography Gas Pyridines Health Toxicology and Mutagenesis Metabolite Alcohol Urine Sulfides Toxicology Biochemistry Mass fragmentography Mass Spectrometry chemistry.chemical_compound Cytosol Biosynthesis Animals Pharmacology Chromatography General Medicine Rats chemistry Liver Rat liver Spectrophotometry Ultraviolet Chromatography Thin Layer |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 6(10) |
| ISSN: | 0049-8254 |
| Popis: | 1. An unidentified oxisuran metabolite which had been observed in animal urine was biosynthesized by incubating [14C]oxisuran with rat liver cytosol. 2. The metabolite, isolated by preparative t.l.c. and extraction, was identified as oxisuran alcohol sulphide by mass fragmentography. Confirmation of this identification was obtained by biosynthesis of the same compound from oxisuran sulphide. 3. The 9000 g supernatant liquid from rat liver was less effective than cytosol in reducing oxisuran to its alcohol sulphide. Neither rat liver fraction reduced oxisuran alcohol sulphoxides to sulphide. 4. The 9000 g fraction oxidized oxisuran and oxisuran alcohol sulphoxide to oxisuran alcohol sulphone. |
| Databáze: | OpenAIRE |
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