Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6
| Autor: | Danielle M. Zerr, Meei-Li Huang, Joshua A. Hill, Richard L. Lawler, Daniel P. Weschke, Terry Stevens-Ayers, John A. Hansen, Michael Boeckh, Keith R. Jerome, Wendy M. Leisenring |
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| Rok vydání: | 2019 |
| Předmět: |
Cytokine profile
medicine.medical_treatment T cell Herpesvirus 6 Human Graft vs Host Disease Article Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Medicine Humans Transplantation biology business.industry Incidence (epidemiology) Chromosomally Integrated Human Herpesvirus 6 Hematopoietic Stem Cell Transplantation Hematology Tissue Donors Cytokine medicine.anatomical_structure surgical procedures operative 030220 oncology & carcinogenesis Immunology Acute Disease biology.protein Cytokines Tumor necrosis factor alpha Antibody business 030215 immunology |
| Zdroj: | Biol Blood Marrow Transplant |
| ISSN: | 1523-6536 |
| Popis: | Acute graft-versus-host-disease (aGVHD) is a major complication following hematopoietic cell transplantations (HCTs). We have shown that HCT recipients in whom either the donor or patient had inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) have a higher incidence of developing more severe aGVHD. Previous studies established that increased proinflammatory cytokines are associated with increased risk for aGVHD and nonrelapse mortality post-HCT. We hypothesized that HCT recipients with donor or recipient iciHHV-6 (iciHHV-6pos HCT cases) will have higher cytokine levels compared with HCT recipients without iciHHV-6 (iciHHV-6neg HCT controls). We identified 64 iciHHV-6pos HCT cases with plasma from days 7, 14, and/or 21 post-HCT and before aGVHD onset in patients who developed aGVHD. We identified 64 iciHHV-6neg HCT controls matched for aGVHD risk factors. We also identified 28 donors with iciHHV-6 and 56 matched donors without iciHHV-6. We measured plasma cytokine concentrations for IL-6, suppression of tumorigenicity 2, T cell immunoglobulin and mucin-domain containing 3, TNFα, soluble TNF receptor 1 (TNFRp55), and C-reactive protein (CRP). We used Mann-Whitney tests and repeated-measures models to compare cytokine levels. iciHHV-6pos HCT cases had higher CRP levels on day 7 and day 21 and higher TNFRp55 levels on day 14 and day 21 compared with iciHHV-6neg HCT controls. These findings were recapitulated in a repeated-measures model. The differences were most evident among patients who subsequently developed aGVHD grades 2 to 4. Additionally, iciHHV-6pos HCT cases had earlier-onset aGVHD (median, 20 versus 27 days post-HCT; P = .02). There were no differences in cytokine levels among healthy donors with or without iciHHV-6. This study demonstrates that HCT recipients with iciHHV-6 have higher proinflammatory cytokines that may be associated with increased risk for aGVHD. |
| Databáze: | OpenAIRE |
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