| Autor: |
Jurga Bernatoniene, Jan Gajdziok, Jan Muselík, Rasa Kaledaite, Rimantas Pečiūra, Kateřina Dvořáčková, Ruta Masteiková |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Pharmaceutical development and technology. 20(7) |
| ISSN: |
1097-9867 |
| Popis: |
The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sensitive polymer Eudragit® FS. Optimal sample of pellets were prepared using microcrystalline cellulose and lactose as excipients and demonstrated excellent technological quality properties such as Hausner ratio (1.07 ± 0.11) and compressibility index (6.73 ± 0.94%) value, spericity (0.87 ± 0.001) and friability (0.22 ± 0.08 N). Pellets were coated by 10-35% (w/w) of Eudragit® FS. Dissolution studies showed that less than 20% of coating could not prevent dissolution of phenols in pH 1.2, 20% Eudragit® FS coating is enough to prevent herbal extract against dissolution in the stomach. There were observed no statistical significant differences between 20% and 25% or higher amount of coating polymer to a dissolution of phenols in low pH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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