ANALYTICAL MODEL TO ESTIMATE EQUIVALENT DOSE FROM INTERNAL NEUTRONS IN PROTON THERAPY OF CHILDREN WITH INTRACRANIAL TUMORS
| Autor: | Phillip J. Taddei, Kyle J Gallagher |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Paper Proton Field (physics) Monte Carlo method 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Proton Therapy Humans Radiology Nuclear Medicine and imaging Neutron Child Proton therapy Physics Neutrons Radiation Radiological and Ultrasound Technology Equivalent dose Brain Neoplasms Radiotherapy Planning Computer-Assisted Public Health Environmental and Occupational Health Radiotherapy Dosage General Medicine Models Theoretical Computational physics 030220 oncology & carcinogenesis Absorbed dose Female Monte Carlo Method |
| Zdroj: | Radiat Prot Dosimetry |
| ISSN: | 1742-3406 |
| Popis: | This study developed a computationally efficient and easy-to-implement analytical model to estimate the equivalent dose from secondary neutrons originating in the bodies (‘internal neutrons’) of children receiving intracranial proton radiotherapy. A two-term double-Gaussian mathematical model was fit to previously published internal neutron equivalent dose per therapeutic absorbed dose versus distance from the field edge calculated using Monte Carlo simulations. The model was trained using three intracranial proton fields of a 9-year-old girl. The resulting model was tested against two intracranial fields of a 10-year-old boy by comparing the mean doses in organs at risk of a radiogenic cancer estimated by the model versus those previously calculated by Monte Carlo. On average, the model reproduced the internal neutron organ doses in the 10-year-old boy within 13.5% of the Monte Carlo at 3–10 cm from the field edge and within a factor of 2 of the Monte Carlo at 10–20 cm from the field edge. Beyond 20 cm, the model poorly estimated H/DRx, however, the values were very small, at |
| Databáze: | OpenAIRE |
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