Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis

Autor: László F.J.M.M Bancsi, Martinus J.C. Eijkemans, Christian Gnoth, L. Nardo, M.J.C. Eijkemans, Thomas Fréour, E.M. Greenblatt, S.L. Broer, M. McIlveen, B. Popovic-Todorovic, Scott M. Nelson, Richard A. Anderson, E. R. Klinkert, Ettore Caroppo, A.B. Copperman, Patrick M.M. Bossuyt, A. La Marca, Lamiya Mohiyiddeen, B.W. Mol, Madeleine Dólleman, P.J.Q. van der Linden, Kannamannadiar Jayaprakasan, H.Y. Ng, M. Dólleman, Iavor K. Vladimirov, Abbas Aflatoonian, C.B. Lambalk, Ben W.J. Mol, K.A. Broeze, Frank J. M. Broekmans, I A J van Rooij, J. van Disseldorp, Jeroen van Disseldorp, Frank J.M. Broekmans, Shanthi Muttukrishna, T. Ebner, Talia Eldar-Geva, Mahnaz Ashrafi, Patrick M. Bossuyt, Simone L. Broer, Brent C. Opmeer, Nick Raine-Fenning, B. C. Opmeer, M. Erdem, Kimiko A. Broeze, L.T. Merce, C. Tomás, Janet Kwee, Jesper M. J. Smeenk
Přispěvatelé: Other departments, Clinical Research Unit, APH - Amsterdam Public Health, Epidemiology and Data Science, 10 Public Health & Methodologie, Obstetrics and Gynaecology, Obstetrics and gynaecology, ICaR - Ischemia and repair
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Fertility and sterility, 100(2), 420-9.e7. Elsevier Inc.
Broer, S L, Dolleman, M, van Disseldorp, J, Broeze, K A, Opmeer, B C, Bossuyt, P M, Eijkemans, M J, Mol, B W J, Lambalk, C B & Broekmans, F J 2013, ' Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis ', Fertility and Sterility, vol. 100, no. 2, pp. 420-429 . https://doi.org/10.1016/j.fertnstert.2013.04.024
Fertility and Sterility, 100(2), 420-429. Elsevier Inc.
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2013.04.024
Popis: Objective To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics, such as female age, in the prediction of excessive response to ovarian hyperstimulation in patients undergoing IVF, and whether their performance differs across clinical subgroups. Design Authors of studies reporting on basal FSH, antimullerian hormone (AMH), or antral follicle count (AFC) in relation to ovarian response to ovarian hyperstimulation were invited to share original data. Random intercept logistic regression models were used to estimate added value of ORTs on patient characteristics, while accounting for between-study heterogeneity. Receiver operating characteristic regression analyses were performed to study the effect of patient characteristics on ORT accuracy. Setting In vitro fertilization clinics. Patient(s) A total of 4,786 women for the main analysis, with a subgroup of 1,023 women with information on all three ORTs. Intervention(s) None. Main Outcome Measure(s) Excessive response prediction. Result(s) We included 57 studies reporting on 32 databases. Female age had an area under the receiver operating characteristic curve of 0.61 for excessive response prediction. Antral follicle count and AMH significantly added prognostic value to this. A model with female age, AFC, and AMH had an area under the receiver operating characteristic curve of 0.85. The combination of AMH and AFC, without age, had similar accuracy. Subgroup analysis indicated that FSH performed significantly worse in predicting excessive response in higher age groups, AFC did significantly better, and AMH performed the same. Conclusion(s) We demonstrate that AFC and AMH add value to female age in the prediction of excessive response and that, for AFC and FSH, the discriminatory performance is affected by female age.
Databáze: OpenAIRE
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