Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
| Autor: | Joana C. D’Avila, Rodrigo de Azeredo Siqueira, Estela Luz Alves, Marília M. Guimarães, Maria Lucia Fleiuss Farias, Adalgiza Mafra Moreno, Laura Maria Carvalho de Mendonça, Aluana Santana Carlos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Turner Syndrome Hyperlipidemias Diseases of the endocrine glands. Clinical endocrinology Transdermal estrogen Insulin resistance Internal medicine insulin resistance medicine Humans Insulin estrogen replacement therapy Transdermal Turner's syndrome Estradiol business.industry medicine.disease RC648-665 hormone replacement therapy Postprandial Endocrinology Hyperlipidemia Estrogen Body Composition Medicine Female Android fat distribution business Body mass index |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 64, Iss 6, Pp 758-763 (2020) Archives of Endocrinology and Metabolism, Issue: ahead, Published: 28 AUG 2020 Archives of Endocrinology and Metabolism, Volume: 64, Issue: 6, Pages: 758-763, Published: 28 AUG 2020 Archives of Endocrinology and Metabolism v.64 n.6 2020 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
| ISSN: | 2359-4292 |
| Popis: | Objective: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Subjects and methods: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. Results: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). Conclusion: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement. |
| Databáze: | OpenAIRE |
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