Fused high b-value diffusion weighted and T2-weighted MR images in staging of pediatric Hodgkin's lymphoma: A pilot study
| Autor: | Bart de Keizer, Suzanne Spijkers, Marrie C.A. Bruin, Annemieke S. Littooij, Rutger A.J. Nievelstein |
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| Rok vydání: | 2019 |
| Předmět: |
Diffusion-Weighted Imaging (DWI)
Male Adolescent Pilot Projects Multimodal Imaging Sensitivity and Specificity Nodal disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Whole-body MRI medicine Journal Article Humans Radiology Nuclear Medicine and imaging Whole Body Imaging cardiovascular diseases Stage (cooking) Child Neoplasm Staging Retrospective Studies Pediatric Hodgkin's lymphoma business.industry General Medicine Fusion imaging medicine.disease High B-Value Hodgkin Disease Magnetic Resonance Imaging Pediatric Hodgkin's Lymphoma Lymphoma Diffusion Magnetic Resonance Imaging Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis T2-weighted imaging Female Mr images T2 weighted business Nuclear medicine |
| Zdroj: | European Journal of Radiology, 121, 108737. Elsevier Ireland Ltd |
| ISSN: | 1872-7727 0720-048X |
| Popis: | Purpose: To evaluate the value of fused high b-value diffusion weighted and T2-weighted MRI compared to T1-weighted imaging, T2-weighted imaging and DWI for staging pediatric Hodgkin's lymphoma. Method: 21 consecutive pediatric patients who underwent whole-body MRI at Hodgkin's lymphoma staging were included. Fused, colorized DWI/T2-weighted images were created. Image sets consisting of (a) T1-weighted, T2-weighted and DWI images and (b) T1-weighted, T2-weighted, DWI and DWI/T2-weighted fused images were reviewed by a radiologist using a cross-over design with blinding and randomization. Scoring was performed using a standardized form, based on detection, characterization and reading time, using a FDG-PET/CT based reference standard. Test characteristics, test agreement to a FDG-PET/CT based reference standard and reading times were calculated. Results: Agreement for whole-body MRI without fused images and FDG-PET/CT was very good for nodal staging (κ = 0.86, 95% CI 0.78-0.93) and extra-nodal staging (κ = 0.90, 95% CI 0.71–1.09). Agreement improved with the addition of the fused DWI/T2-weighted images (κ = 0.92 95% CI 0.87-0.97 (nodal staging), κ = 0.92 95% CI 0.76–1.08 (extra-nodal staging). Sensitivity and specificity for staging nodal disease were 99 % and 95% respectively for whole-body MRI including DWI/T2-weighted fused images (versus 88 % and 97 % without fused images) and 100 % and 99 % for extra-nodal disease (83 % and 100 % without fused images). Disease stage for MRI including fused DWI/T2-weighted images agreed with the reference standard in 18 out of 21 patients. Conclusions: The addition of DWI/T2-weighted fusion images to T1-weighted, T2-weighted and DWI whole-body MRI might shorten reading times and might improve the diagnostic performance of whole-body MRI in staging pediatric Hodgkin's lymphoma. |
| Databáze: | OpenAIRE |
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