Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury
| Autor: | Qiang Zhu, Xiao-Qiao Dong, Yong-Feng Shen, Zu-Yong Zhang, Quan Du, Zhi-Hao Che, Ding-Bo Yang, Wen-Hua Yu, Li Jiang, Hao Wang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Traumatic brain injury medicine.medical_treatment Clinical Biochemistry Inflammation Lung injury Biochemistry Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine White blood cell Brain Injuries Traumatic otorhinolaryngologic diseases Humans Medicine Macrophage Migration-Inhibitory Factors Aged business.industry Cerebral infarction Biochemistry (medical) Glasgow Coma Scale 030208 emergency & critical care medicine General Medicine Middle Aged respiratory system Prognosis medicine.disease medicine.anatomical_structure Cytokine Immunology Female Macrophage migration inhibitory factor medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinica Chimica Acta. 469:99-104 |
| ISSN: | 0009-8981 |
| Popis: | Background Macrophage migration inhibitory factor (MIF) is a well-known pro-inflammatory cytokine. Serum MIF concentrations are associated with the severity and prognosis of ischemic stroke. Methods In this prospective, observational study, white blood cell (WBC) count and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and MIF among 108 severe traumatic brain injury (TBI) patients and 108 controls were measured. We determined whether serum MIF concentrations are associated with inflammation, severity, in-hospital major adverse events (IMAEs) (i.e., in-hospital mortality, acute lung injury, acute traumatic coagulopathy, progressive hemorrhagic injury and posttraumatic cerebral infarction) and long-term clinical outcome (i.e., 6-month functional outcome) after TBI. Results As compared to the controls, serum CRP, IL-6, TNF-α and MIF concentrations were significantly increased. MIF concentrations correlated with WBC count, CRP, IL-6 and TNF-α concentrations and Glasgow coma scale (GCS) scores. MIF in serum was independently associated with IMAEs and long-term clinical outcome. Area under receiver operating characteristic curve of MIF concentrations was similar to GCS scores'. Moreover, MIF concentrations markedly improved the predictive value of GCS scores for 6-month unfavorable outcome. Conclusion Increased serum MIF concentrations have close relation to inflammation, trauma severity and clinical outcomes, substantializing MIF as a good prognostic biomarker after TBI. |
| Databáze: | OpenAIRE |
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