Value of estradiol response after human chorionic gonadotropin administration in predicting in vitro fertilization success
| Autor: | Suzanne T Baker, David A. Grainger, Stan A. Beyler, Dawne A. Lowden, William R. Meyer, Stephen G. Somkuti |
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| Rok vydání: | 1999 |
| Předmět: |
Infertility
Adult medicine.medical_specialty medicine.medical_treatment Endometriosis Fertilization in Vitro Biology Chorionic Gonadotropin Miscarriage Human chorionic gonadotropin Cohort Studies Pregnancy medicine Humans Embryo Implantation Prospective Studies Unexplained infertility Gynecology In vitro fertilisation Estradiol Age Factors Obstetrics and Gynecology medicine.disease Treatment Outcome Reproductive Medicine Gestation Female |
| Zdroj: | Fertility and sterility. 72(3) |
| ISSN: | 0015-0282 |
| Popis: | Objective: To determine whether the serum E 2 response after the administration of exogenous hCG is predictive of outcome during IVF. Design: Prospective, noncomparative cohort. Setting: Two academic centers and one private-practice IVF program. Patient(s): Two hundred twenty-two couples undergoing IVF for infertility arising from ovarian dysfunction, asthenoteratospermia, endometriosis, tubal disease, or unexplained infertility. Main Outcome Measure(s): Implantation, pregnancy, and miscarriage rates were compared in cycles that demonstrated an increase, decrease, or plateau in the serum E 2 level on the day after hCG administration. The effects of age, cause of infertility, and maximum E 2 value on outcome were evaluated. Result(s): Ninety-two cycles resulted in a clinical pregnancy and 130 cycles failed. Of 115 cycles in which the E 2 level rose, 42 (37%) resulted in an ongoing pregnancy; among cycles with plateauing E 2 responses, 20 of 69 (29%) resulted in a pregnancy. Fifteen of 38 (39%) of cycles exhibiting a drop in serum E 2 resulted in an ongoing pregnancy. No statistically significant differences in ongoing pregnancy rates were noted in the increasing, plateauing, or decreasing E 2 response groups. Conclusion(s): E 2 values obtained on the day after hCG administration are not predictive of outcome in women undergoing IVF. |
| Databáze: | OpenAIRE |
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