Hepatosplenic Hodgkin lymphoma without lymphadenopathy following reversible methotrexate-associated lymphoproliferative disorder
| Autor: | Shuji Inoue, Kumiko Tanaka, Tsutomu Shinohara, Yoshihito Iwahara, Keishi Naruse, Yuki Tsukazaki |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Pathology Population Hepatosplenomegaly Lymphadenopathy Lymphoproliferative disorders Spontaneous remission Gastroenterology Virus Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans skin and connective tissue diseases education Aged 80 and over 030203 arthritis & rheumatology education.field_of_study business.industry medicine.disease Hodgkin Disease Infliximab Methotrexate Liver 030220 oncology & carcinogenesis Rheumatoid arthritis Female medicine.symptom business Immunosuppressive Agents Spleen medicine.drug |
| Zdroj: | Modern Rheumatology. 27:372-375 |
| ISSN: | 1439-7609 1439-7595 |
| Popis: | Lymphoproliferative disorders (LPDs) occur more frequently in rheumatoid arthritis (RA) patients treated with immunosuppressive agents than in the non-RA population. However, the various forms of disease progression have not yet been elucidated in detail. We encountered a case of Epstein-Barr virus (EBV)-positive atypical polymorphous LPD in the cervical and intraabdominal lymph nodes with hepatosplenomegaly in an 88-year-old female with RA who had taken infliximab and methotrexate (MTX) for six years. Although spontaneous remission occurred following the withdrawal of infliximab and MTX, reversible LPD evolved into hepatosplenic Hodgkin lymphoma without lymphadenopathy presenting as a cholestatic febrile illness. Our findings suggest that the recurrent lesions of MTX-associated LPDs may not always coincide with the primary lesion and may present unexplained findings based on various extranodal diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|