Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study
| Autor: | Xavier Boquet, Elisabet Palomera, Josep Oriola, Gloria Aranda, Manuel Puig-Domingo, Immaculada Cadenas, Mireia Mora, Jesús Blanco, Mateu Serra-Prat, Immaculada Falcón, Lidia Martínez Sánchez |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Aging Time Factors Frail Elderly Health Status Population Dehydroepiandrosterone Motor Activity Article Sex hormone-binding globulin Cognition Receptors Glucocorticoid Risk Factors Internal medicine medicine Prevalence Humans Prospective Studies education Prospective cohort study Depression (differential diagnoses) Aged Metabolic Syndrome education.field_of_study Polymorphism Genetic biology Depression Testosterone (patch) General Medicine DNA Endocrinology Phenotype Spain biology.protein Geriatric Depression Scale Female Gene polymorphism Geriatrics and Gerontology Psychology Follow-Up Studies |
| Zdroj: | Age (Dordrecht, Netherlands). 34(3) |
| ISSN: | 1574-4647 |
| Popis: | The purpose of this study is to assess the potential relationships of circulating IGF-I, adrenal and gonadal steroids, and polymorphism ER22/23EK of the glucocorticoid receptor (GC-R) gene with nutritional, functional and cognitive deterioration in a group of elderly people living independently. This is a population-based prospective study with 313 individuals (160 women and 153 men, 76.7 ± 7 years) who participated. A physical exam, evaluation of functional capacity (Barthel scale), cognitive function (mini-mental state examination-MMSE), geriatric depression scale (GDS), mininutritional assessment (MNA-SF) and cardiometabolic status were performed at basal time point and at 2 years of follow-up. Biological measurements included cortisol, dehydroepiandrosterone (DHEA), DHEA sulphate, testosterone, estradiol, IGF-I and polymorphism ER22/23EK of the GC-R gene. Estradiol was associated with MNA-SF decrease over time (p |
| Databáze: | OpenAIRE |
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