Recombinant Wolbachia heat shock protein 60 (HSP60) mediated immune responses in patients with lymphatic filariasis
| Autor: | Subash Babu, Rangarajan Badri Narayanan, Guruswamy Manokaran, S. Elango, C. Shiny, N.S.A. Krushna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment T cell Immunology chemical and pharmacologic phenomena Biology Lymphocyte Activation Microbiology Peripheral blood mononuclear cell T-Lymphocytes Regulatory Brugia malayi Article Immunomodulation Interferon-gamma Immune system Elephantiasis Filarial Bacterial Proteins Transforming Growth Factor beta parasitic diseases medicine Animals Humans CTLA-4 Antigen IL-2 receptor Child Symbiosis Cells Cultured Interleukin-2 Receptor alpha Subunit Chaperonin 60 biochemical phenomena metabolism and nutrition biology.organism_classification Recombinant Proteins Interleukin-10 Interleukin 10 Infectious Diseases Cytokine medicine.anatomical_structure bacteria Wolbachia Female |
| Popis: | Wolbachia, an endosymbiont present in filarial nematodes, have been implicated in a variety of roles, including the worm development and survival. Elucidation of the role of Wolbachia in filarial nematode biology and pathogenesis has become the focus of many studies and its contribution to parasite survival or immune response is still unclear. Recombinant Wolbachia HSP60 decreases T cell activation and lymphoproliferation in filarial infected people compared to endemic controls as observed by the assessment of T cell activation markers and cytokine responses in the peripheral blood mononuclear cells. Reduced T cell activation may be linked to T regulatory cell activity since it is associated with increased expression of CTLA4 and CD25 on CD4(+) T cells in filarial infected group upon stimulation with recombinant Wolbachia HSP60. In addition, elevated interleukin-10 and TGF-β cytokines corroborate the reduced CD4(+) T cell activation and interferon-γ observed upon recombinant Wolbachia HSP60 stimulation in filarial patients. Hence, these findings indicate that Wolbachia HSP60 may also contribute to the immune modulation seen in filarial patients. |
| Databáze: | OpenAIRE |
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